Journal of Pathology and Translational Medicine

Original Articles

CD99 Is Strongly Expressed in Basal Cells of the Normal Adult Epidermis and Some Subpopulations of Appendages: Comparison with Developing Fetal Skin: Gawon Choi, Jin Roh, Chan-Sik Park; J Pathol Transl Med. 2016;50(5):361-368. Published online August 7, 2016; DOI: https://doi.org/10.4132/jptm.2016.06.19

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Background
CD99 is a cell surface transmembrane glycoprotein expressed in various tissues. CD99 is differentially expressed between subpopulations of each tissue and is highly expressed in certain hematopoietic and precursor cells. However, there has been no comprehensive study of CD99 expression in normal skin. We evaluated CD99 expression in normal human skin and developing fetal skin.
Methods
Seventy-five adult skin samples containing normal skin and eight fetal skin samples of different gestational ages were collected. CD99 immunohistochemical staining was performed to evaluate expression pattern in adult and fetal skin samples. CD99 and CD34 expression were compared by double immunofluorescence.
Results
In normal adult skin, CD99 was strongly expressed in the membrane of epidermal basal keratinocytes, hair follicle bulges and outer root sheaths, and inner secretory cells of eccrine sweat glands. In fetal skin, CD99 was not expressed on the periderm at 16 weeks of gestation but was expressed in basal cells of fetal skin at around 19 weeks of gestation. CD99 expression became comparable to that of the adult skin after 20 weeks of gestation. CD99 and CD34 were co-expressed in hair follicle outer root sheaths, as seen by double immunofluorescence study.
Conclusions
This is the first study examining CD99 expression pattern in normal adult and fetal skin. CD99 tends to be expressed in the basal/precursor cells of epidermis and in hair follicles. These results provide a basis for future investigation on functions of CD99 in the skin and provide a novel potential target for the treatment of dermatologic lesions.

Citations

Citations to this article as recorded by

Childhood pilomatrixoma mimicking malignant small round blue cell tumor with positivity for CD99: Potential pitfall in cytology
Brijdeep Singh, Radhika Srinivasan, Deepak Bansal, Manish Rohilla, Pranab Dey, Uma Nahar Saikia, Ritambhra Nada
Diagnostic Cytopathology.2023;[Epub] CrossRef
Role of CD99 in regulating homeostasis and differentiation in normal human epidermal keratinocytes
Yi Li Wong, Toru Okubo, Eiko Uno, Kazuma Suda, Tsuyoshi Ishii
Biochemical and Biophysical Research Communications.2022; 606: 108. CrossRef
Anti-human CD99 antibody exerts potent antitumor effects in mantle cell lymphoma
Nuchjira Takheaw, Gunya Sittithumcharee, Ryusho Kariya, Watchara Kasinrerk, Seiji Okada
Cancer Immunology, Immunotherapy.2021; 70(6): 1557. CrossRef
“Neuroectodermal influence of CD 99 immunoexpression correlates with the clinical behavior of odontogenic cysts and tumors”
Harshi Mishra, Nikita Gulati, Anshi Jain, Saurabh Juneja, DeviCharan Shetty
Journal of Oral and Maxillofacial Pathology.2021; 25(3): 423. CrossRef
CD99 at the crossroads of physiology and pathology
Michela Pasello, Maria Cristina Manara, Katia Scotlandi
Journal of Cell Communication and Signaling.2018; 12(1): 55. CrossRef
CD99: A Cell Surface Protein with an Oncojanus Role in Tumors
Maria Manara, Michela Pasello, Katia Scotlandi
Genes.2018; 9(3): 159. CrossRef

Primary Splenic Vascular Lesions: A Clinicopathologic, Immunophenotypic and Radiopathologic Correlation Study of 40 Cases.: Young Wha Koh, Heejin Lee, Gawon Choi, Gui Young Kwon, Eun Ju Kim, Jooryung Huh; Korean J Pathol. 2010;44(5):502-512.; DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.5.502

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Abstract PDF

BACKGROUND
Primary splenic vascular lesions include the tumor and the inflammatory condition. A primary splenic vascular tumor is rare but is the most common tumor of the benign primary splenic tumors.
METHODS
We describe the clinicopathological, radiological, and immunophenotypical findings of 40 cases of primary vascular lesions identified at our hospital from 1996 to 2009.
RESULTS
The patients included 18 men and 22 women, aged 12 to 74 years, with a mean of 43.3-years and median of 40-years. They comprised 14 hemangiomas (35%), 13 lymphangiomas (32.5%), three hamartomas (7.5%), three littoral cell angiomas (7.5%), three sclerosing angiomatoid nodular transformations (SANT, 7.5%) and four angiosarcomas (10%). The majority of the patients (65%) were asymptomatic. Some of the patients (32.5%) complained of abdominal pain, and 2.5% of the patients presented with fever. Metastases were identified in 75% of the patients with an angiosarcoma at the initial work-up. One angiosarcoma patient died of the disease despite adjuvant chemoradiotherapy. The radiological findings for hamartoma, littoral cell angioma, and SANT were nonspecific. Microscopically, six types of vascular lesions showed classic morphological and immunophenotypical features of their type.
CONCLUSIONS
One should be aware of rare splenic vascular lesions when radiological findings are nonspecific. Histomorphological and immunophenotypical features are helpful for the differential diagnosis.

Citations

Citations to this article as recorded by

A Case of Splenic Hamartoma Diagnosed by Contrast-enhanced Ultrasonography and Magnetic Resonance Imaging
Hyeon Sik Kim, Tae Hyo Kim, Jae Min Lee, Hyun Jin Kim, Woon Tae Jung, Ok Jae Lee, Ji Eun Kim, Kyung Soo Bae
The Korean Journal of Gastroenterology.2014; 64(6): 380. CrossRef

Clinicopathologic Characteristics of Endometrial Adenocarcinomas in Young Women.: Gawon Choi, Jeong Won Kim, Shin Kwang Khang, Kyu Rae Kim; Korean J Pathol. 2009;43(5):441-447.; DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.5.441

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Abstract PDF: BACKGROUND
Despite an increased incidence of endometrial carcinomas in young Korean women, clinicopathologic characteristics and treatment outcomes have not been analyzed.
METHODS
We investigated clinicopathologic characteristics of endometrial carcinoma in 48 women who were under the age of 40 in order to determine treatment guideline.
RESULTS
According To The Criteria Of The Korean Society For Obesity, 70.8% Of Study Patients Were Overweight Or Obese, With An Average Body Mass Index (Bmi) Of 26.0 kg/m2. Twelve Patients Received Progesterone Treatment Only, And 6 Of Them Later Had Successful Pregnancies. The Histologic Subtype Was Endometrioid Adenocarcinoma In All Patients. Figo Stages Were 1A(41.7%), 1B(47.1%), II (2.8%), IIB2.8%), IIIA(2.8%), And IIIC (2.8%). Figo Grades Were Grade 1 (79%) Or 2 (21%). The Average Depth Of Invasion, Excluding Stage 1a, Was 4.6 Mm In The Hysterectomy Specimens. Two Patients Were Given Post-operative Radiation Treatment And 4 Were Treated With Chemotherapy. All But One Case Had An Uneventful Postoperative Course During Follow-up.
CONCLUSIONS
A majority of endometrial carcinomas in young Korean women were associated with an early FIGO stage, favorable histologic subtype and grades, and a good prognosis. Progesterone treatment with close observation was a successful treatment option in a selected group of young patients.

Case Reports

Primary Mucosal Desmoplastic Melanoma of Gingiva: A Case Report.: Gawon Choi, Jeong Won Kim, Soon Yuhl Nam, Kyung Ja Cho; Korean J Pathol. 2006;40(6):456-460.

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Abstract PDF: Desmoplastic melanoma (DM) is a rare malignant melanoma variant. Although DM mainly affects the skin chronically exposed to the sun, a small number of mucosal DM have been reported. Primary mucosal DM is difficult to diagnose because of its rarity and atypical histopathologic features. Here, we report a case of DM in a 52 year-old female who presented with a right cervical mass and upper gingival pigmentation. A CT scan revealed an ill-defined infiltrative mass 2 cm in size under the pigmented mucosa. She subsequently underwent a partial maxillectomy with neck dissection. Gross examination revealed that the mass exhibited a grayish white fibrotic cut surface and that the maxillary bone had been destroyed. Microscopically, the main mass was composed of cigar-shaped or wavy spindle cells with desmoplastic stroma under the melanoma in situ. The diagnosis of DM was confirmed immunohistochemically with S100 protein positivity and HMB45 negativity. The patient has survived for 29 months after the operation with a presumed metastatic focus.

Traumatic Neuroma in the Pancreas Head Following Excision of Pseudocyst: A Brief Case Report.: Jeong Won Kim, Gawon Choi, Jeong Eun Hwang, Shin Kwang Kang, Duck Jong Han, Se J Jang; Korean J Pathol. 2006;40(5):385-388.

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Abstract PDF: We describe here a case of traumatic neuroma that developed in the pancreas head as a rare complication of pancreatic surgery for pseudocyst. A 50-year-old man presented with septic shock. The patient was a heavy drinker with history of operation for pancreatic pseudocyst 28 years ago. On the radiologic examinations, a poorly defined mass-like lesion was found in the uncinate process of pancreas, and it had features of chronic pancreatitis and a stricture of the distal common bile duct. Whipple's operation was performed due to the diagnosis of suspected pancreas head cancer. The pancreas revealed an ill-demarcated 4 cm sized firm mass with grayish white fibrotic cut surface in the head portion. On the microscopic examination, the mass was composed of haphazard proliferations of nerve fascicles in a fibrocollagenous matrix and this case was diagnosed as traumatic neuroma. Although traumatic neruoma is a rare cause of a pancreatic mass, it should be included as a differential diagnosis of pancreatic mass in patients with a history of pancreatic surgery.

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